Name: Deca 250
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Deca 250

Deca, also recognized as Deca Durabolin or Nandrolone Decanoate is a steroid commonly employed for tissue regeneration after severe injuries or prolonged illnesses. It is frequently prescribed as an anabolic steroid for the management of osteoporosis in post-menopausal women. Deca Durabolin has become one of the most widely utilized Androgenic and Anabolic Steroids (AAS) worldwide.

Deca is a prescription medication that must be prescribed by a licensed medical practitioner. Self-administration of these anabolic steroids is not advisable. Your physician will determine the appropriate dosage and duration for your treatment. Due to the potential complications associated with these anabolic steroids, it is essential to engage in a comprehensive discussion with your doctor before starting Deca anabolic steroids.

The use of these anabolic steroids may lead to some common side effects, including edema (swelling of the feet, ankles, and hands), nausea, acne, fluid retention, and breast enlargement. If you experience any of these side effects or others that are severe, it is crucial to promptly contact your physician.

Nandrolone Decanoate, known as Deca Durabolin, made its first appearance in the medical literature in 1960. It was initially developed by the pharmaceutical company Organon and subsequently introduced for medical use under the brand name Deca Durabolin. Over time, Deca Durabolin has become one of the most widely utilized Androgenic and Anabolic Steroids (AAS) worldwide.

Nandrolone phenylpropionate was the initial form of nandrolone introduced, followed later by nandrolone decanoate.

What is Deca?

Nandrolone Decanoate, commonly known as Deca or Deca Durabolin, is an anabolic steroid medication. It falls under the category of androgen and anabolic steroid medications (AAS) and is typically administered through intramuscular or subcutaneous injections given once every 1-4 weeks.

Androgens encompass a group of hormones crucial in regulating the development and maintenance of masculine traits, such as the growth of body hair and deepening of the voice, as well as reproductive functions. Testosterone is the most prevalent androgen. Anabolic steroids are synthetic derivatives of androgens, including testosterone, and they are utilized for various purposes.

These specific anabolic steroids are commonly employed for tissue regeneration after severe injuries or prolonged illnesses. Deca Durabolin may also be prescribed to enhance lean body mass in cases of negative nitrogen imbalance. However, it is more frequently utilized in the treatment of post-menopausal women suffering from osteoporosis, a condition characterized by thin and brittle bones. Deca Durabolin mimics the effects of the male sex hormone, testosterone.

History

In 1960, Nandrolone Decanoate, commonly known as Deca Durabolin, made its inaugural appearance in the medical literature. Originally created by the pharmaceutical company Organon, it was subsequently marketed under the brand name Deca Durabolin for medical purposes. Rapidly gaining popularity, Deca Durabolin swiftly emerged as one of the most widely utilized Androgenic and Anabolic Steroids (AAS) on a global scale.

The introduction of nandrolone phenylpropionate preceded that of nandrolone decanoate as the first form of nandrolone made available.

Other Names

This medication is primarily known as Nandrolone decanoate, which serves as both its USAN (United States Adopted Name) and BAN (British Adopted Name). Nevertheless, it has also been occasionally labeled as Nandrolone decylate.

Moreover, Nandrolone is available in the market under multiple brand names, including Deca Durabolin, Deca Durabol, Decaneurabol, Retabolil, and Metadec, among others.

How Does Deca Work?

Nandrolone decanoate operates on the DNA level, mimicking the actions of the body’s naturally produced male sex hormone, testosterone. Elevated Nandrolone levels exert a beneficial impact on calcium metabolism and contribute to the augmentation of bone mass, particularly in individuals with osteoporosis.

Chemical Structure

Nandrolone Decanoate, also known as Nandrolone 17β-decanoate, is a synthetic estrane steroid derivative of testosterone. This compound falls into the category of steroid esters, which are characterized by a steroid moiety containing a carboxylic acid ester group. Specifically, it is the C17β decylate (decanoate) ester of nandrolone, which itself is the 19-demethylated analogue of testosterone.

In terms of chemical taxonomy, Nandrolone Decanoate can be classified as follows:

Kingdom: Organic compounds

Super Class: Lipids and lipid-like molecules

Class: Steroids and steroid derivatives

Subclass: Steroid esters

Direct parent: Steroid esters

Alternative parents: Estrogens and derivatives, Delta-4-steroids, 3-oxo delta-4-steroids, Carboxylic acid esters, Monocarboxylic acids and derivatives, Cyclohexanones, Organic oxides, Hydrocarbon derivatives

Substituents: 3-oxo delta-4-steroids, 3-oxosteroid, Carbonyl group, Aliphatic homopolycyclic compound, Carboxylic acid derivative, carboxylic acid ester, Cyclohexanone, Delta-4-steroid, Cyclic ketone, Estrane skeleton

Molecular framework: Aliphatic homopolycyclic compounds

External descriptors: Steroid ester

This classification provides a comprehensive description of Nandrolone Decanoate’s chemical structure and its place within the broader context of organic compounds and steroids.

Absorption

The pharmacokinetics of nandrolone decanoate (Deca Durabolin) administered intramuscularly exhibit the following characteristics at various dosage levels:

For a 50 mg intramuscular dose:

Mean Cmax: 2.14 ng/mL

Mean Tmax: 30 hours

Mean AUC: Approximately 400 h*ng/mL

For a 100 mg intramuscular dose:

Mean Cmax: 4.26 ng/mL

Mean Tmax: 30 hours

Mean AUC: Approximately 862 h*ng/mL

For a 150 mg intramuscular dose:

Mean Cmax: 5.16 ng/mL

Mean Tmax: Approximately 72 hours

Mean AUC: Approximately 1261 h*ng/mL

Pharmacology

Pharmacodynamics (Mechanism of Action on the Body):

Deca Durabolin functions as a prodrug, enhancing drug absorption and primarily consists of nandrolone or a nandrolone ester. This compound operates as an androgenic and anabolic steroid, acting as an agonist for AR, a biological target shared with androgens like testosterone and DHT. In comparison to testosterone, nandrolone decanoate exhibits heightened anabolic effects while minimizing androgenic impacts. Consequently, it is deemed a more suitable choice among anabolic-androgenic steroids (AAS) for use in women and children.

Apart from its anabolic androgenic steroid properties, Deca Durabolin demonstrates minimal estrogenic activities, primarily through its metabolite estradiol, and moderate progestogenic activity. Like other AAS, nandrolone can also exhibit antigonadotropic effects, potentially resulting in side effects such as gynecomastia and fluid retention. To mitigate these effects, combining nandrolone with anti-estrogenic steroids may be necessary.

Pharmacokinetics (How the Body Responds to the Drug):

When administered via intramuscular injection, Deca Durabolin or Deca anabolic steroids form a long-lasting depot within the muscle, remaining unchanged and gradually absorbed into the body. Upon entering circulation, it converts into nandrolone, the active form of the drug.

Following an intramuscular injection, Deca Durabolin’s anabolic steroid levels can sharply peak within 24 to 48 hours, followed by a gradual decline to baseline levels over two to three weeks. The drug’s bioavailability varies depending on the injection site, with the highest observed when administered into the gluteal muscle.

Deca Durabolin rapidly undergoes hydrolysis in the bloodstream by esterases, transforming into nandrolone, which has a terminal half-life of approximately one hour or even less. Metabolism of nandrolone anabolic steroids typically takes place in the liver and closely resembles that of the male sex hormone, testosterone.

The elimination half-life of Deca Durabolin, when administered via intramuscular injection, typically falls within the range of 6 to 12 days. Nandrolone, along with its metabolites, is excreted in urine in conjugated forms.

Metabolization

Deca Durabolin undergoes initial hydrolysis to form nandrolone, a process likely mediated by PDE7B. Nandrolone is subsequently metabolized into urinary metabolites, specifically 19-norandrosterone, 19-noretiocholanolone, and 19-norepiandrosterone. The transformation of 19-norandrosterone involves 3-O-glucuronidation, catalyzed by enzymes UGT2B7, UGT 1A4, UGT2B4, UGT1A3, and UGT1A1. Similarly, 19-noretiocholanolone also undergoes 3-O-glucuronidation, facilitated by enzymes UGT2B7, UGT2B4, UGT1A4, UGT1A10, UGT1A3, and UGT1A1.

Method of Elimination

Deca Durabolin is typically excreted in the form of metabolites in urine, but information regarding its elimination through feces is not readily accessible. Studies conducted by observing cattle have revealed that approximately 30% of nandrolone is excreted through feces.

Half-Life

Deca Durabolin exhibits an absorption half-life of approximately 6 days and an elimination half-life of roughly 4.3 hours. Additional research findings indicate that Deca Durabolin has terminal half-lives of approximately 7.1, 11.7, and 11.8 hours for doses of 50 mg, 100 mg, and 150 mg, respectively.

What Does Deca Look Like?

Deca Durabolin is an injectable solution with a faint yellow hue and an oily texture. Typically, it is supplied in a clear 1 mL glass vial, containing approximately 50mg/ml of the compound, and it is accompanied by a needle.

What is Deca Durabolin Used for?

Medical Applications

Osteoporosis

Osteoporosis is a medical condition characterized by the weakening and fragility of bones, particularly in areas like the feet, ankles, and knees. In individuals with osteoporosis, bones become so brittle that even minor incidents, such as a slight fall, bending over, or even coughing, can lead to fractures.

Fractures associated with osteoporosis most frequently occur in vulnerable bones such as the spine, hips, or wrists. This condition typically arises when the body’s ability to generate new bone tissue fails to keep pace with the loss of existing bone. Osteoporosis is more prevalent among older individuals, with a higher incidence observed in women after menopause, a stage marking the cessation of menstruation, known as post-menopausal osteoporosis.

Deca Durabolin is a commonly prescribed medication for postmenopausal women suffering from osteoporosis. It enhances bone strength and health, reducing the risk of fractures, while also preserving bone density and resistance to fractures.

Other Medical Uses

Deca Durabolin finds application in the treatment of various medical conditions, including anemia related to chronic kidney diseases, kidney failure, aplastic anemia, inoperable breast cancer, and in patients undergoing long-term corticosteroid therapy. It is also employed in the management of conditions characterized by a negative nitrogen balance.

Deca Durabolin has demonstrated remarkable efficacy in preserving lean body mass, making it an off-label choice for patients with conditions like HIV/AIDS and other wasting syndromes that result in significant weight loss (more than 10% of total body weight). Historically, it has been employed for a range of purposes, including post-operative and pre-operative use to increase lean mass, treating weight loss during convalescence or due to illnesses, severe trauma, and certain cases of growth deficiency in children.

Nandrolone esters, such as those found in Deca Durabolin, can also be employed in androgen replacement therapy to address androgen deficiency in men, although their primary use is as anabolic agents.

In summary, Deca Durabolin is used for the following medical purposes:

Osteoporosis in postmenopausal women

Anemia associated with chronic kidney diseases

Kidney (renal) failure

Aplastic anemia

Inoperable breast cancer

Management of negative nitrogen imbalance

Preservation of lean body mass in HIV/AIDS patients and other wasting syndromes

Maintenance of postoperative and preoperative lean body mass

Androgen replacement therapy

Non-Medical Uses

Beyond its extensive medical applications, Deca Durabolin is renowned for its performance-enhancing and physique-building properties. For an extended period, competitive athletes, bodybuilders, and powerlifters have turned to Deca Durabolin to enhance their physical attributes and improve their athletic performance.

Typically, it is administered during 8-12 week bulking cycles, often alongside a specific quantity of testosterone as a foundational component. Research indicates that when nandrolone is used in isolation (without a foundational testosterone component), it can suppress the body’s natural testosterone production by affecting components of the blood-testis barrier. To counteract reduced testosterone levels, it is generally recommended to use nandrolone alongside external testosterone as a base.

Deca Durabolin stands as one of the most prevalent injectable androgenic anabolic steroids (AASs) globally, favored by athletes, bodybuilders, and powerlifters due to its favorable anabolic-to-androgenic effect ratio and milder side effects.

Nandrolone in Bodybuilding

Nandrolone is renowned for its ability to enhance muscle mass in professional bodybuilders and powerlifters. This slow-acting anabolic steroid facilitates nitrogen retention in muscles, ultimately resulting in increased muscle size.

Nandrolone Effects on Athletes

It is generally discouraged for athletes to use anabolic steroids. Current objective research findings present conflicting perspectives on whether these substances genuinely enhance athletic performance by boosting muscle strength.

Moreover, the utilization of nandrolone anabolic steroids can lead to abnormal weight gain due in part to fluid retention, a prevalent and risky side effect associated with steroid therapy.

Administration Methods for Nandrolone

The preferred approach for administering Nandrolone involves injecting it into the muscle tissue. The effectiveness of Deca Durabolin decanoate largely hinges on the injection site chosen. While any intramuscular site suffices, the drug exhibits its highest bioavailability when injected into the gluteal muscles.

Subcutaneous Injection as an Alternative

Although intramuscular injections are the most common mode of administration, subcutaneous injection has proven to be an equally effective alternative. However, this method offers enhanced ease, convenience, and significantly less discomfort when contrasted with intramuscular injection.

Important Note

Typically, a licensed medical professional administers this injection in a hospital or clinic. Nevertheless, if your healthcare provider advises you to self-administer this medication at home, they will provide instructions on how to prepare and administer it safely. Always adhere strictly to your doctor’s prescription and guidance, and never exceed the recommended dosage.

Proper disposal of the used injection is crucial. Avoid discarding it in regular trash bins. Instead, use a designated sharps container for disposal. If you don’t have access to one, consult your doctor or pharmacist for guidance on safe disposal methods.

Dosage for Women on Androgen Replacement Therapy

For women undergoing general androgen replacement therapy, the recommended dosage typically falls in the range of 25 to 50mg of Deca administered via intramuscular injection. This injection is administered every 6 to 12 weeks.

In the treatment of postmenopausal osteoporosis and inoperable breast cancer, a commonly prescribed regimen involves a dosage of approximately 50 mg administered through intramuscular injection every 2 to 4 weeks.

For pediatric patients aged 2 to 13 years with anemia associated with chronic kidney disease, the standard protocol typically includes a dosage of 25 to 50mg administered via intramuscular injection every 3 to 4 weeks.

Adverse Effects

The potential side effects associated with Deca Durabolin hinge on factors like dosage, treatment purpose, duration of use, and individual sensitivity. A spectrum of side effects, ranging from common to uncommon and rare, has been documented in individuals adhering to recommended dosages. Notably, the primary side effect in postmenopausal women using Nandrolone for osteoporosis treatment is virilization, which can also manifest as injection site redness and rashes.

Common Side Effects

Among the observed side effects, the following are more frequently encountered:

Priapism: A condition characterized by prolonged and often painful erections without sexual stimulation, lasting beyond four hours.

Virilization: The development of masculine traits in women, including hoarseness of voice, acne, excessive facial and body hair growth, increased libido, and clitoral enlargement.

Acne

Breast Enlargement

Less Common Side Effects

Additional, albeit less common, side effects may include:

Altered Sexual Interest: Prolonged use of nandrolone can affect sexual interests.

Hypercalcemia: Elevated calcium levels in the blood.

Prostate Gland Enlargement: Abnormal enlargement of the prostate gland, rarely leading to cancer.

Fluid Retention (Edema): Accumulation of fluids in tissues.

Leg Cramps

Allergic Reactions: Skin rashes, hives, itching, and swelling of the face, lips, or tongue.

Sleep Disturbances

Spermatogenesis Inhibition: Decreased sperm production in the testes.

Erectile Dysfunction

Breast Lumps

Gynecomastia: Enlargement of breast tissue in men due to hormonal imbalances.

Chills

Dark Urine

Increased Penis Size in Prepubertal Boys

Clitoral Hypertrophy

Testicular Atrophy: Reduction in testicle size and function.

Increased Pubic Hair Growth

Oligomenorrhea: Irregular menstruation.

Amenorrhea: Absence of menstruation.

Nausea

Diarrhea

Mood Swings

Bladder Irritability and Reduced Urine Flow

Epididymitis: Enlargement of the epididymis.

Hyperlipidemia: Elevated levels of lipids (fats) in the blood.

Rare Side Effects

In addition to the above effects, some exceedingly rare side effects associated with Nandrolone include:

Liver Cancer

Abdominal Bloating

Abnormal Liver Function

Jaundice

Peliosis Hepatis: The development of multiple blood-filled cavities in the liver.

Oily Skin

Greasy Hair

Venous Blood Clots

Pruritus: Severe itchiness.

Exanthema: Widespread rashes throughout the body.

Elevated Bilirubin Levels in the Blood

Averting Gynecomastia

As previously mentioned, Deca Durabolin is categorized as an Androgenic and Anabolic Steroid (AAS). It is noteworthy that Deca Durabolin exhibits minimal estrogenic activities, primarily through its estradiol metabolite, along with moderate progestogenic effects. Similar to other AAS, nandrolone can also manifest anti-gonadotropic properties, which means it can suppress or inhibit the actions of one or both of the gonadotropins—specifically Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH).

These actions can result in various side effects, such as fluid retention, a condition that hinders the efficient elimination of excess fluid from tissues, and gynecomastia, which leads to the enlargement or swelling of breast tissues in men, commonly referred to as “man boobs.”

Estrogen Imbalance

Clearly, these conditions arise from an imbalance in estrogen and testosterone levels, with higher estrogen and lower testosterone levels being the culprits. To prevent the onset of these issues, it is typically recommended to combine Deca Durabolin with other anti-estrogenic steroids.

Utilizing anti-estrogenic steroids effectively lowers the estrogen levels in your body, reinstating a harmonious equilibrium between estrogen and testosterone. Consequently, this assists in alleviating problems like gynecomastia and fluid retention.

Precautions

Before beginning Deca Durabolin treatment, it is essential to engage in a comprehensive discussion with your healthcare provider. This conversation should encompass various aspects of your life, including your lifestyle, occupation, dietary habits, allergies, and medical history.

Alcohol + Allergies

If you choose to consume alcohol, it is advisable to consult your doctor beforehand. While alcohol consumption typically does not result in any negative interactions with the medication, it is recommended to exercise moderation in alcohol consumption while taking your medication.

If you experience a severe allergic reaction to the medication or have a history of allergies related to Deca Durabolin, please discontinue your medication and promptly inform your doctor.

When Taken During Pregnancy

Deca Durabolin poses significant risks during pregnancy, potentially causing harm to both the expectant mother and the developing fetus. As such, it is strongly discouraged to use this medication while pregnant. If you suspect you are pregnant or become pregnant while on this medication, it is crucial to promptly inform your healthcare provider.

The effects of Deca Durabolin on breastfeeding have not been extensively studied. Therefore, it is advisable to seek guidance from your doctor before considering its use if you are nursing.

Deca Durabolin does not have a known impact on vision or cognitive function, making activities such as driving and operating machinery generally safe while taking the medication.

Individuals with liver issues should exercise caution when using nandrolone, as it can have a severe impact on liver function. It is imperative to consult your healthcare provider before beginning the medication if you have liver problems.

In summary, it is essential to communicate with your healthcare provider if you have a history of or currently experience any of the following conditions:

Diabetes

Breast cancer

Heart disease

Kidney disease

Liver disease

Prostate disease

Porphyria (an inherited blood-related disorder)

Previous allergic reactions to nandrolone

Pregnancy or attempts to conceive

Breastfeeding

Children under three years of age

Brain-related issues (e.g., head injuries or tumors)

Mental or mood disorders

Respiratory problems such as asthma

Personal or family history of substance use disorders (e.g., substance overuse or addiction)

Intestinal problems

Pancreatic diseases

Epilepsy

Always consult with your healthcare provider to ensure the safe and appropriate use of Deca Durabolin given your medical history and circumstances.

Drug Interactions

It is essential to engage in a comprehensive conversation with your healthcare provider about your medical history, existing medical conditions, and any medications you are currently taking when considering Deca Durabolin. This is crucial because Deca Durabolin has the potential to interact with other drugs in your system, potentially leading to serious health complications.

Furthermore, it’s important to note that certain medications, like aromatase inhibitors such as anastrozole and selective estrogen receptor modulators like tamoxifen and raloxifene, have the capacity to interfere with and suppress the estrogenic effects of Deca Durabolin. Additionally, reductase inhibitors such as finasteride and dutasteride may inhibit the breakdown of nandrolone in specific “androgenic tissues” such as the skin, hair follicles, and the prostate gland, potentially increasing the likelihood of androgenic side effects.

This medication has the potential to interact unfavorably with several other drugs, leading to adverse effects. These drugs include:

Leuprolide

Diabetic medications

Medications for prostate gland issues (such as dutasteride, saw palmetto, finasteride)

Goserelin

Warfarin

Erythropoietin (utilized for anemia treatment)

Carbamazepine

Please refrain from initiating, discontinuing, or modifying any of your medications while taking this treatment without consulting your doctor first.

Past Medical History

If you have any allergies or if you have an allergic history with Deca Durabolin, immediately stop the medication and consult your doctor as soon as possible. Deca Durabolin does not have any known records of interacting with food particles. However, it is better to consult your doctor if you have any queries regarding your food intake.

Dietary Restrictions

If you experience any allergies or have a history of allergic reactions to Deca Durabolin, it is crucial to discontinue the medication promptly and seek immediate advice from your healthcare provider. Deca Durabolin is not associated with any documented interactions with food. Nonetheless, if you have any questions or concerns about your dietary choices while taking this medication, it is advisable to consult your doctor for guidance.

What to Do if You Miss a Dose

In the event that you inadvertently miss a dose of the injection, please take it promptly upon recollection. However, if you recollect it only after 24 hours have elapsed since the scheduled time, it is advisable to forego the missed dosage and seek guidance from your healthcare provider regarding the appropriate course of action.

Please be advised: In no circumstances should an additional dose of the medication be taken.

Overdosing

It is crucial to follow your doctor’s prescription diligently and never exceed the recommended dosage of your medication, under any circumstances. However, if an overdose does occur, it is essential to promptly consult your doctor.

Chronic overdose of anabolic steroids can lead to a range of adverse effects. In men, it may result in suppressed testosterone levels, leading to reduced spermatogenesis (resulting in a very low sperm count), testicular shrinkage, erectile dysfunction, and decreased libido. In women, it can lead to suppressed estrogen and progesterone levels, reduced ovulation, amenorrhea, and clitoromegaly (unusual enlargement of the clitoris).

Overdosing can also manifest with neuropsychiatric, cardiovascular, and hepatic adverse side effects. Hepatic adverse effects are particularly common with alkylated anabolic steroids like nandrolone.

If you observe someone overdosing on Deca Durabolin and experiencing severe side effects such as difficulty breathing or loss of consciousness, please dial 911 or contact the nearest local poison control center immediately.

How to Store

Please store this medication in a cool, dry location, well out of the reach of children and pets. It is essential to understand that using this drug without a valid prescription from a registered medical practitioner can result in serious health risks. Additionally, this medication has the potential for misuse, and distributing or sharing it is not only highly dangerous but also illegal.

If you are administering this medication at home, we strongly recommend consulting your doctor or pharmacist for comprehensive guidance on proper storage. Remember to dispose of any unused medication once it has surpassed its expiration date, which can be found on the label.

Conclusion

Benefits:

Medical Applications: Deca is prescribed for osteoporosis, anemia related to chronic kidney diseases, inoperable breast cancer, and other conditions. It can help enhance bone density and lean body mass.

Performance Enhancement: Athletes and bodybuilders use Deca to build muscle and improve athletic performance. It can help increase muscle size and strength.

Low Estrogenic Activity: Deca has minimal estrogenic effects, making it suitable for use in women and reducing the risk of estrogen-related side effects.

Long-Lasting Effects: Its long half-life allows for less frequent injections, which can be more convenient for patients.

Risks:

Prescription Required: Deca is a prescription medication and should only be used under the supervision of a licensed medical practitioner. Self-administration is not advisable.

Side Effects: Common side effects include edema, nausea, acne, and breast enlargement. More severe side effects are possible, including priapism, virilization in women, and fluid retention.

Interactions: Deca can interact with other medications, and its use should be carefully monitored in individuals taking other drugs.

Misuse and Overdose: Using Deca without a valid prescription or in excessive doses can lead to serious health risks, including hormonal imbalances, liver issues, and cardiovascular problems.

In summary, Deca Durabolin can be beneficial for specific medical conditions but should be used cautiously under medical supervision. Its misuse for performance enhancement is not recommended due to the associated health risks. Always consult with a healthcare provider for proper guidance and monitoring when considering Deca as a treatment option.

Usage and Dosage

Benefits

Side Effects

2 reviews for Deca 250

Rated 4 out of 5
Tyler – July 30, 2023
Impressive results, definitely recommend.
Rated 5 out of 5
Nicholas – July 30, 2023
Efficient and professional service.